Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol | ID-8; ID-8 | Homo sapiens | |
callistephin | - |
Homo sapiens | |
malvin | - |
Homo sapiens | |
additional information | isozyme hCA II is inhibited by flavonoids, poor inhibition by pelargonin; isozyme hCA I is inhibited by flavonoids, poor inhibition by pelargonin | Homo sapiens | |
oenin | - |
Homo sapiens | |
silychristin | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required, metalloenzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00915 | - |
- |
Homo sapiens | P00918 | - |
- |
Purification (Comment) | Organism |
---|---|
native isozyme hCA I from human blood erythrocytes by L-tyrosine-sulfanilamide affinity chromatography and elution with 1.0 M NaCl/25 mM Na2HPO4, pH 6.3 | Homo sapiens |
native isozyme hCA II from human blood erythrocytes by L-tyrosine-sulfanilamide affinity chromatography and elution with 0.1 M NaCH3COO/0.5 M NaClO4, pH 5.6 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
additional information | enzyme activity measurements determining CO2-hydratase activity or determining esterase activity with 4-nitrophenyl acetate as substrate | Homo sapiens | ? | - |
? | |
additional information | enzyme activity measurements determining CO2-hydratase activity or determining esterase activity with 4-nitrophenylacetate as substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CA1 | - |
Homo sapiens |
CA2 | - |
Homo sapiens |
hCA I | - |
Homo sapiens |
HCA II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
esterase activity assay at room temperature with 4-nitrophenyl acetate as substrate | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
esterase activity assay at with 4-nitrophenylacetate as substrate | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00035 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | oenin | |
0.0013 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | silychristin | |
0.0187 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | oenin | |
0.0433 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | silychristin | |
0.0462 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | callistephin | |
0.0533 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | 1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol | |
0.1155 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | malvin | |
0.231 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | malvin | |
0.3465 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | callistephin | |
0.693 | - |
versus CO2 hydration activity, pH and temperature not specified in the publication | Homo sapiens | 1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol |