Application | Comment | Organism |
---|---|---|
drug development | Drosophila beta-CA represents a highly active mitochondrial enzyme that is a potential model enzyme for anti-parasitic drug development | Drosophila melanogaster |
Cloned (Comment) | Organism |
---|---|
gene DmBCA, phylogenetic analysis, expression in Spodoptera frugiperda Sf9 cells using the baculovirus transfection system | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-acetamido-1,3,4-thiadiazole-2-sulfonamide | - |
Drosophila melanogaster | |
Br- | - |
Drosophila melanogaster | |
Cl- | - |
Drosophila melanogaster | |
ClO4- | poor inhibition | Drosophila melanogaster | |
CN- | - |
Drosophila melanogaster | |
CNO- | - |
Drosophila melanogaster | |
F- | - |
Drosophila melanogaster | |
H2NSO2NH2 | - |
Drosophila melanogaster | |
H2NSO3H | - |
Drosophila melanogaster | |
HCO3- | - |
Drosophila melanogaster | |
HS- | - |
Drosophila melanogaster | |
HSO3- | - |
Drosophila melanogaster | |
I- | - |
Drosophila melanogaster | |
N3- | - |
Drosophila melanogaster | |
NO2- | - |
Drosophila melanogaster | |
NO3- | - |
Drosophila melanogaster | |
Ph-AsO3H2 | - |
Drosophila melanogaster | |
Ph-B(OH)2 | - |
Drosophila melanogaster | |
SCN- | - |
Drosophila melanogaster | |
SO42- | - |
Drosophila melanogaster | |
sulfamide | - |
Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Drosophila melanogaster | 5739 | - |
additional information | subcellular localization study, overview | Drosophila melanogaster | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Drosophila melanogaster | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
gene DmBCA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Drosophila melanogaster | CO2 + H2O | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | dynamic light scattering analysis and gel filtration | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
beta-CA | - |
Drosophila melanogaster |
beta-carbonic anhydrase | - |
Drosophila melanogaster |
CO2 hydratase | - |
Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Drosophila melanogaster |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
950000 | - |
CO2 | pH 8.3, 20°C | Drosophila melanogaster |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
assay at | Drosophila melanogaster |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000049 | - |
5-acetamido-1,3,4-thiadiazole-2-sulfonamide | pH 8.3, 20°C | Drosophila melanogaster | |
0.15 | - |
sulfamide | pH 8.3, 20°C | Drosophila melanogaster | |
0.15 | - |
H2NSO2NH2 | pH 8.3, 20°C | Drosophila melanogaster | |
0.67 | - |
CN- | pH 8.3, 20°C | Drosophila melanogaster | |
0.73 | - |
CNO- | pH 8.3, 20°C | Drosophila melanogaster | |
0.8 | - |
F- | pH 8.3, 20°C | Drosophila melanogaster | |
0.97 | - |
Cl- | pH 8.3, 20°C | Drosophila melanogaster | |
1.01 | - |
HS- | pH 8.3, 20°C | Drosophila melanogaster | |
1.04 | - |
Br- | pH 8.3, 20°C | Drosophila melanogaster | |
1.12 | - |
N3- | pH 8.3, 20°C | Drosophila melanogaster | |
1.18 | - |
I- | pH 8.3, 20°C | Drosophila melanogaster | |
1.28 | - |
SCN- | pH 8.3, 20°C | Drosophila melanogaster | |
1.29 | - |
HSO3- | pH 8.3, 20°C | Drosophila melanogaster | |
1.36 | - |
SO42- | pH 8.3, 20°C | Drosophila melanogaster | |
2.45 | - |
H2NSO3H | pH 8.3, 20°C | Drosophila melanogaster | |
22.4 | - |
Ph-B(OH)2 | pH 8.3, 20°C | Drosophila melanogaster | |
26.9 | - |
HCO3- | pH 8.3, 20°C | Drosophila melanogaster | |
28.6 | - |
NO2- | pH 8.3, 20°C | Drosophila melanogaster | |
32.6 | - |
Ph-AsO3H2 | pH 8.3, 20°C | Drosophila melanogaster | |
43.7 | - |
NO3- | pH 8.3, 20°C | Drosophila melanogaster | |
200 | - |
ClO4- | above, pH 8.3, 20°C | Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
evolution | phylogenetic analysis of beta-class carbonic anhydrases in invertebrates, overview | Drosophila melanogaster |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
110000 | - |
CO2 | pH 8.3, 20°C | Drosophila melanogaster |