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Literature summary for 4.2.1.1 extracted from
- Carbonic anhydrase inhibitors: The membrane-associated isoform XV is highly inhibited by inorganic anions (2009), Bioorg. Med. Chem. Lett., 19, 1155-1158.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| azide | shows low micromolar inhibition against CA XV | Mus musculus |  |
| bicarbonate | shows low micromolar inhibition against CA XV | Mus musculus | |
| bromide | - |
Mus musculus | |
| Carbonate | - |
Mus musculus | |
| chloride | - |
Mus musculus | |
| cyanide | shows low micromolar inhibition against CA XV | Mus musculus | |
| fluoride | - |
Mus musculus | |
| hydrogen sulfide | shows low micromolar inhibition against CA XV | Mus musculus | |
| hydrogen sulfite | shows low micromolar inhibition against CA XV | Mus musculus | |
| Iodide | - |
Mus musculus | |
| additional information | isoform CA XV is not inhibited by tetrafluoroborate | Mus musculus | |
| nitrate | - |
Mus musculus | |
| nitrite | - |
Mus musculus | |
| perchlorate | - |
Mus musculus | |
| phenylarsonic acid | - |
Mus musculus | |
| phenylboronic acid | - |
Mus musculus | |
| sulfamate | - |
Mus musculus | |
| sulfamide | - |
Mus musculus | |
| sulfate | shows low micromolar inhibition against CA XV | Mus musculus | |
| thiocyanate | shows low micromolar inhibition against CA XV | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CO2 + H2O | - |
Mus musculus | H2CO3 | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca XV | - |
Mus musculus |
| carbonic anhydrase XV | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0082 | - |
bicarbonate | isozyme CA XV | Mus musculus | |
| 0.0085 | - |
azide | isozyme CA XV | Mus musculus | |
| 0.0092 | - |
hydrogen sulfide | isozyme CA XV | Mus musculus | |
| 0.0094 | - |
cyanide | isozyme CA XV | Mus musculus | |
| 0.0095 | - |
sulfate | isozyme CA XV | Mus musculus | |
| 0.0097 | - |
hydrogen sulfite | isozyme CA XV | Mus musculus | |
| 0.0101 | - |
thiocyanate | isozyme CA XV | Mus musculus | |
| 0.0276 | - |
cyanide | isozyme CA XV | Mus musculus | |
| 0.0374 | - |
sulfamide | isozyme CA XV | Mus musculus | |
| 0.0544 | - |
fluoride | isozyme CA XV | Mus musculus | |
| 0.0612 | - |
nitrite | isozyme CA XV | Mus musculus | |
| 0.0678 | - |
phenylboronic acid | isozyme CA XV | Mus musculus | |
| 0.0682 | - |
phenylarsonic acid | isozyme CA XV | Mus musculus | |
| 0.0687 | - |
nitrate | isozyme CA XV | Mus musculus | |
| 0.0853 | - |
chloride | isozyme CA XV | Mus musculus | |
| 0.0986 | - |
sulfamate | isozyme CA XV | Mus musculus | |
| 0.104 | - |
bromide | isozyme CA XV | Mus musculus | |
| 0.106 | - |
Carbonate | isozyme CA XV | Mus musculus | |
| 0.288 | - |
Iodide | isozyme CA XV | Mus musculus | |
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