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Literature summary for 4.2.1.1 extracted from

  • Sugimoto, A.; Ikeda, H.; Tsukamoto, H.; Kihira, K.; Ishioka, M.; Hirose, J.; Hata, T.; Fujioka, H.; Ono, Y.
    Timolol activates the enzyme activities of human carbonic anhydrase I and II (2010), Biol. Pharm. Bull., 33, 301-306.
    View publication on PubMed
Search for more literature for 4.2.1.1

Activating Compound

Activating Compound Comment Organism Structure
timolol the formal name is (2S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol, timolol noncompetitively activates carbonic anhydrases I and II activities, timolol increases the value of Vmax but does not influence the value of Km Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 CO2 isoform CA II, in the presence of 4.5 mM timolol, at 25°C in 0.01 M HEPES buffer (pH 7.4) Homo sapiens
0.013
-
 CO2 isoform CA II, in the presence of 2.0 mM timolol, at 25°C in 0.01 M HEPES buffer (pH 7.4) Homo sapiens
0.02
-
 CO2 isoform CA I, in the presence of 1.5 or 3.0 mM timolol, at 25°C in 0.01 M HEPES buffer (pH 7.4) Homo sapiens
13
-
 CO2 isoform CA II, at 25°C in 0.01 M HEPES buffer pH 7.4, in the absence of timolol Homo sapiens
19
-
 CO2 isoform CA I, at 25°C in 0.01 M HEPES buffer pH 7.4, in the absence of timolol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

Synonyms Comment Organism
CA I isoform Homo sapiens
CA II isoform Homo sapiens
carbonic anhydrase I isoform Homo sapiens
carbonic anhydrase II isoform Homo sapiens