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Literature summary for 4.2.1.1 extracted from

  • Wilkinson, B.L.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen, S.A.
    Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides (2008), J. Med. Chem., 51, 1945-1953.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
4-ethynylbenzenesulfonamide
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
 Homo sapiens
acetazolamide systemic carbonic anhydrase inhibitor Homo sapiens
brinzolamide potent inhibitor of isozymes CA II Homo sapiens
dichlorophenamide systemic carbonic anhydrase inhibitor Homo sapiens
dorzolamide potent inhibitor of isozymes CA II Homo sapiens
ethoxazolamide systemic carbonic anhydrase inhibitor Homo sapiens
indisulam potent inhibitor of CA IX Homo sapiens
methazolamide systemic carbonic anhydrase inhibitor Homo sapiens
additional information NaClO4 is not inhibitory Homo sapiens
topiramate powerful inhibitor of CA II Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

Synonyms Comment Organism
CA I isozyme Homo sapiens
CA II isozyme Homo sapiens
CA IX isozyme Homo sapiens
carbonic anhydrase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000016
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000021
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000023
-
 4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000025
-
 4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000028
-
 4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000003
-
 brinzolamide isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000005
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000051
-
 4-ethynylbenzenesulfonamide
-
 Homo sapiens
0.0000054
-
 4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000075
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000076
-
 4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000008
-
 ethoxazolamide isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000081
-
 4-ethynylbenzenesulfonamide
-
 Homo sapiens
0.0000082
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000084
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000087
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000089
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000009
-
 dorzolamide isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000091
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000093
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000094
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000099
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0000105
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000012
-
 acetazolamide isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000013
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000014
-
 methazolamide isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000025
-
 ethoxazolamide isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000025
-
 acetazolamide isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000027
-
 methazolamide isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000028
-
 4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000034
-
 ethoxazolamide isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000038
-
 dichlorophenamide isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000047
-
 brinzolamide isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000048
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00005
-
 methazolamide isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00005
-
 dichlorophenamide isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000052
-
 dorzolamide isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000085
-
 4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000088
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0001
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000101
-
 4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00011
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00012
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00012
-
 4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00012
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000121
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00013
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00013
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000134
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000235
-
 4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00025
-
 acetazolamide isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00038
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000427
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.000432
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00044
-
 4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00045
-
 brinzolamide isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00046
-
 1-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-4-(4-sulfamoylphenyl)-1H-1,2,3-triazole isozyme CA II, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0005
-
 dorzolamide isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00056
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.00108
-
 4-ethynylbenzenesulfonamide
-
 Homo sapiens
0.0012
-
 dichlorophenamide isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0025
-
 4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0043
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0043
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0044
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0044
-
 1-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-4-(4-sulfamoylphenyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.005
-
 4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.005
-
 4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens
0.0053
-
 4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole isozyme CA I, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C Homo sapiens