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Literature summary for 4.2.1.1 extracted from

  • Innocenti, A.; Muehlschlegel, F.A.; Hall, R.A.; Steegborn, C.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions (2008), Bioorg. Med. Chem. Lett., 18, 5066-5070.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetazolamide
-
Candida albicans
acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Cryptococcus neoformans
azide
-
Candida albicans
azide
-
Cryptococcus neoformans
bromide
-
Candida albicans
bromide
-
Cryptococcus neoformans
Carbonate potent inhibitor Candida albicans
Carbonate
-
Cryptococcus neoformans
chloride
-
Candida albicans
chloride
-
Cryptococcus neoformans
cyanide potent inhibitor Candida albicans
cyanide weak inhibitor Cryptococcus neoformans
fluoride
-
Candida albicans
fluoride
-
Cryptococcus neoformans
hydrogen carbonate
-
Candida albicans
hydrogen carbonate
-
Cryptococcus neoformans
hydrogen sulfide
-
Candida albicans
hydrogen sulfide best Can2 anion inhibitor Cryptococcus neoformans
hydrogen sulfite
-
Candida albicans
hydrogen sulfite
-
Cryptococcus neoformans
Iodide
-
Candida albicans
Iodide worst Can2 anion inhibitor Cryptococcus neoformans
isocyanide
-
Candida albicans
isocyanide
-
Cryptococcus neoformans
additional information perchlorate is not an inhibitor in concentrations up to 200 mM Candida albicans
additional information Can2 is not inhibited by perchlorate Cryptococcus neoformans
nitrate
-
Candida albicans
nitrate
-
Cryptococcus neoformans
nitrite
-
Candida albicans
nitrite
-
Cryptococcus neoformans
phenyl arsonic acid weak Nce103 inhibitor Candida albicans
phenyl arsonic acid
-
Cryptococcus neoformans
phenyl boronic acid weak Nce103 inhibitor Candida albicans
phenyl boronic acid
-
Cryptococcus neoformans
sulfamic acid
-
Candida albicans
sulfamic acid weak inhibitor Cryptococcus neoformans
sulfamide
-
Candida albicans
sulfamide
-
Cryptococcus neoformans
sulfate weak Nce103 inhibitor Candida albicans
sulfate
-
Cryptococcus neoformans
Thiocyanide
-
Candida albicans
Thiocyanide
-
Cryptococcus neoformans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Cryptococcus neoformans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
Candida albicans H2CO3
-
r
CO2 + H2O
-
Cryptococcus neoformans H2CO3
-
r

Synonyms

Synonyms Comment Organism
beta-carbonic anhydrase
-
Candida albicans
beta-carbonic anhydrase
-
Cryptococcus neoformans
Can2
-
Cryptococcus neoformans
Nce103
-
Candida albicans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
390000
-
CO2 at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
800000
-
CO2 at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000105
-
acetazolamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.000132
-
acetazolamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.01
-
Carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.011
-
cyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.3
-
sulfamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.37
-
hydrogen sulfide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.52
-
azide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.53
-
nitrite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.54
-
hydrogen sulfite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.6
-
hydrogen sulfide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.6
-
Carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.62
-
hydrogen carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.65
-
Thiocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.69
-
nitrate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.69
-
fluoride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.7
-
sulfamic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.71
-
hydrogen sulfite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.73
-
azide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.75
-
hydrogen carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.81
-
phenyl boronic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.85
-
chloride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.86
-
sulfate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.86
-
fluoride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.87
-
phenyl arsonic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.92
-
chloride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.92
-
nitrate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.94
-
bromide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
0.94
-
Thiocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.96
-
nitrite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
0.99
-
sulfamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
1
-
bromide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
1.01
-
isocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
1.11
-
Iodide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
1.18
-
isocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
1.4
-
Iodide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
8.22
-
sulfamic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
13.56
-
cyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
14.15
-
sulfate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
30.84
-
phenyl arsonic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
30.85
-
phenyl boronic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans