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Literature summary for 4.2.1.1 extracted from

  • Temperini, C.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies (2008), Bioorg. Med. Chem. Lett., 18, 4282-4286.
    View publication on PubMed
Search for more literature for 4.2.1.1

Crystallization (Commentary)

Crystallization (Comment) Organism
isozyme carbonic anhydrase II complexed with inhibitor EMD 486019 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
667-coumate
-
 Homo sapiens
667-coumate
-
 Mus musculus
acetazolamide
-
 Homo sapiens
acetazolamide
-
 Mus musculus
EMD 486019 EMD 486019 acts as a strong inhibitor of isozymes carbonic anhydrase II, VB, VII, IX, XII, and XIV Homo sapiens
EMD 486019
-
 Mus musculus
topiramate
-
 Homo sapiens
topiramate
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P00918
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Mus musculus H2CO3
-
 r
CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

Synonyms Comment Organism
CA I isoform Homo sapiens
CA II isoform Homo sapiens
CA III isoform Homo sapiens
CA IV isoform Homo sapiens
CA IX isoform Homo sapiens
CA VA isoform Homo sapiens
CA VB isoform Homo sapiens
CA VI isoform Homo sapiens
CA VII isoform Homo sapiens
CA XII isoform Homo sapiens
CA XIII isoform Mus musculus
CA XIV isoform Homo sapiens
carbonic anhydrase
-
 Mus musculus
carbonic anhydrase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000038
-
 topiramate isozyme carbonic anhydrase XII Homo sapiens
0.00000057
-
 acetazolamide isozyme carbonic anhydrase XII Homo sapiens
0.0000009
-
 topiramate isozyme carbonic anhydrase VII Homo sapiens
0.0000025
-
 acetazolamide isozyme carbonic anhydrase VII Homo sapiens
0.00001
-
 topiramate isozyme carbonic anhydrase II Homo sapiens
0.000011
-
 acetazolamide isozyme carbonic anhydrase VI Homo sapiens
0.000012
-
 acetazolamide isozyme carbonic anhydrase II Homo sapiens
0.000012
-
 667-coumate isozyme carbonic anhydrase XII Homo sapiens
0.000013
-
 EMD 486019 isozyme carbonic anhydrase XII Homo sapiens
0.000013
-
 EMD 486019 isozyme carbonic anhydrase XIV Homo sapiens
0.000014
-
 EMD 486019 isozyme carbonic anhydrase II Homo sapiens
0.000017
-
 acetazolamide isozyme carbonic anhydrase XIII Mus musculus
0.000018
-
 EMD 486019 isozyme carbonic anhydrase IX Homo sapiens
0.000018
-
 EMD 486019 isozyme carbonic anhydrase VB Homo sapiens
0.000019
-
 EMD 486019 isozyme carbonic anhydrase VII Homo sapiens
0.000021
-
 667-coumate isozyme carbonic anhydrase II Homo sapiens
0.000023
-
 667-coumate isozyme carbonic anhydrase VII Homo sapiens
0.000024
-
 667-coumate isozyme carbonic anhydrase IV Homo sapiens
0.000025
-
 acetazolamide isozyme carbonic anhydrase IX Homo sapiens
0.00003
-
 topiramate isozyme carbonic anhydrase VB Homo sapiens
0.000034
-
 667-coumate isozyme carbonic anhydrase IX Homo sapiens
0.000041
-
 acetazolamide isozyme carbonic anhydrase XIV Homo sapiens
0.000045
-
 topiramate isozyme carbonic anhydrase VI Homo sapiens
0.000047
-
 topiramate isozyme carbonic anhydrase XIII Mus musculus
0.000054
-
 acetazolamide isozyme carbonic anhydrase VB Homo sapiens
0.000058
-
 topiramate isozyme carbonic anhydrase IX Homo sapiens
0.000063
-
 acetazolamide isozyme carbonic anhydrase VA Homo sapiens
0.000063
-
 topiramate isozyme carbonic anhydrase VA Homo sapiens
0.000066
-
 EMD 486019 isozyme carbonic anhydrase XIII Mus musculus
0.000074
-
 acetazolamide isozyme carbonic anhydrase IV Homo sapiens
0.00025
-
 acetazolamide isozyme carbonic anhydrase I Homo sapiens
0.00025
-
 topiramate isozyme carbonic anhydrase I Homo sapiens
0.000653
-
 667-coumate isozyme carbonic anhydrase VI Homo sapiens
0.000654
-
 EMD 486019 isozyme carbonic anhydrase VI Homo sapiens
0.000682
-
 EMD 486019 isozyme carbonic anhydrase VA Homo sapiens
0.00072
-
 667-coumate isozyme carbonic anhydrase VB Homo sapiens
0.000755
-
 667-coumate isozyme carbonic anhydrase XIV Homo sapiens
0.000765
-
 667-coumate isozyme carbonic anhydrase VA Homo sapiens
0.000842
-
 EMD 486019 isozyme carbonic anhydrase IV Homo sapiens
0.00105
-
 667-coumate isozyme carbonic anhydrase XIII Mus musculus
0.00146
-
 topiramate isozyme carbonic anhydrase XIV Homo sapiens
0.00345
-
 667-coumate isozyme carbonic anhydrase I Homo sapiens
0.0036
-
 EMD 486019 isozyme carbonic anhydrase I Homo sapiens
0.0049
-
 topiramate isozyme carbonic anhydrase IV Homo sapiens
0.2
-
 acetazolamide isozyme carbonic anhydrase III Homo sapiens
0.7
-
 667-coumate isozyme carbonic anhydrase III Homo sapiens
0.74
-
 EMD 486019 isozyme carbonic anhydrase III Homo sapiens
0.78
-
 topiramate isozyme carbonic anhydrase III Homo sapiens