Cloned (Comment) | Organism |
---|---|
CA I and CA II cDNA expressed in Escherichia coli BL21 (DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H,1H,2H,2H-perfluorodecyl sulfamate | - |
Homo sapiens | |
1H,1H,2H,2H-perfluorooctyl sulfamate | - |
Homo sapiens | |
1H,1H-perfluoroethyl sulfamate | - |
Homo sapiens | |
1H-perfluoroisopropyl sulfamate | - |
Homo sapiens | |
2-phenylethyl sulfamate | - |
Homo sapiens | |
3-chloropropyl sulfamate | - |
Homo sapiens | |
7-alpha-hydroxydehydroepiandrosterone sulfamate | - |
Homo sapiens | |
7-oxodehydroepiandrosterone sulfamate | - |
Homo sapiens | |
7alpha-hydroxyepiandrosterone sulfamate | - |
Homo sapiens | |
acetazolamide | - |
Homo sapiens | |
benzyl sulfamate | - |
Homo sapiens | |
but-3-enyl sulfamate | - |
Homo sapiens | |
but-3-ynyl sulfamate | - |
Homo sapiens | |
cholesteryl sulfamate | - |
Homo sapiens | |
cyclohexyl sulfamate | - |
Homo sapiens | |
cyclopentyl sulfamate | - |
Homo sapiens | |
dehydroepiandrosterone sulfamate | CA II inhibitor | Homo sapiens | |
ethoxzolamide | - |
Homo sapiens | |
ethyl sulfamate | - |
Homo sapiens | |
fluorenylmethyl sulfamate | - |
Homo sapiens | |
isopropyl sulfamate | - |
Homo sapiens | |
methazolamide | - |
Homo sapiens | |
methyl sulfamate | - |
Homo sapiens | |
n-butyl sulfamate | - |
Homo sapiens | |
n-decyl sulfamate | CA II inhibitor | Homo sapiens | |
n-dodecyl sulfamate | - |
Homo sapiens | |
n-hexadecyl sulfamate | - |
Homo sapiens | |
n-octadecyl sulfamate | - |
Homo sapiens | |
n-octyl sulfamate | inhibition of hCA I, hCA II, and hCA IX | Homo sapiens | |
n-pentyl sulfamate | - |
Homo sapiens | |
n-propyl sulfamate | - |
Homo sapiens | |
n-tetradecyl sulfamate | most potent CA I inhibitor | Homo sapiens | |
n-undecyl sulfamate | - |
Homo sapiens | |
p-biphenylmethyl sulfamate | - |
Homo sapiens | |
p-methylbenzyl sulfamate | - |
Homo sapiens | |
phenyl sulfamate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozymes I and II | Homo sapiens | 5829 | - |
membrane | transmembrane tumor-associated isozyme IX | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzymes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA | - |
Homo sapiens |
CA I | - |
Homo sapiens |
CA II | - |
Homo sapiens |
CA IX | - |
Homo sapiens |
carbonic anhydrase | - |
Homo sapiens |
carbonic anhydrase isozyme I | - |
Homo sapiens |
carbonic anhydrase isozyme II | - |
Homo sapiens |
carbonic anhydrase isozyme IX | - |
Homo sapiens |
hCA I | - |
Homo sapiens |
HCA II | - |
Homo sapiens |
hCA IX | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000007 | - |
n-decyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0000011 | - |
2-phenylethyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0000027 | - |
p-methylbenzyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0000034 | - |
benzyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0000047 | - |
n-undecyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000008 | - |
ethoxzolamide | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000009 | - |
n-dodecyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00001 | - |
n-dodecyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000012 | - |
acetazolamide | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000012 | - |
2-phenylethyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000013 | - |
7alpha-hydroxyepiandrosterone sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000013 | - |
p-methylbenzyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000014 | - |
methazolamide | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000014 | - |
benzyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000015 | - |
n-tetradecyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000017 | - |
n-undecyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000022 | - |
n-hexadecyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000023 | - |
7-oxodehydroepiandrosterone sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000023 | - |
n-decyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000025 | - |
ethoxzolamide | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.000025 | - |
acetazolamide | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000027 | - |
methazolamide | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000034 | - |
ethoxzolamide | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000058 | - |
n-pentyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.00006 | - |
cyclohexyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000065 | - |
7alpha-hydroxyepiandrosterone sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00007 | - |
n-butyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000076 | - |
7-oxodehydroepiandrosterone sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000087 | - |
n-tetradecyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000097 | - |
n-hexadecyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.00012 | - |
n-octadecyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000126 | - |
n-pentyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000129 | - |
n-octadecyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000142 | - |
1H,1H,2H,2H-perfluorodecyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00015 | - |
n-tetradecyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.00027 | - |
n-dodecyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.000279 | - |
1H-perfluoroisopropyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000335 | - |
1H,1H,2H,2H-perfluorooctyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.000386 | - |
but-3-enyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00043 | - |
n-undecyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.000458 | - |
1H,1H-perfluoroethyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00053 | - |
n-decyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.00057 | - |
3-chloropropyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000633 | - |
but-3-ynyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00071 | - |
n-pentyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.00075 | - |
n-propyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.00078 | - |
methazolamide | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.000845 | - |
1H,1H-perfluoroethyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.000883 | - |
but-3-enyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0009 | - |
acetazolamide | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.001 | - |
p-methylbenzyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.001 | - |
methyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.001 | - |
ethyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.001 | - |
n-propyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.001 | - |
isopropyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.001 | - |
n-butyl sulfamate | pH 7.5, 20°C, HCA IX | Homo sapiens | |
0.00158 | - |
1H-perfluoroisopropyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0031 | - |
n-butyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.00354 | - |
1H-perfluoroisopropyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.0037 | - |
n-propyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.004 | - |
7alpha-hydroxyepiandrosterone sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.0041 | - |
2-phenylethyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.0041 | - |
7-oxodehydroepiandrosterone sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.0045 | - |
fluorenylmethylsulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.00462 | - |
3-chloropropyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.0055 | - |
ethyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0059 | - |
but-3-ynyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.006 | - |
methyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.0076 | - |
benzyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.0078 | - |
1H,1H-perfluoroethyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.008 | - |
1H,1H,2H,2H-perfluorooctyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.009 | - |
1H,1H,2H,2H-perfluorodecyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.01 | - |
isopropyl sulfamate | pH 7.5, 20°C, HCA II | Homo sapiens | |
0.038 | - |
ethyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.038 | - |
fluorenylmethyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.04 | - |
methyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.058 | - |
n-hexadecyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.059 | - |
cyclohexyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.065 | - |
n-octadecyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.4 | - |
1H,1H,2H,2H-perfluorooctyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.69 | - |
isopropyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.8 | - |
but-3-enyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
0.99 | - |
but-3-ynyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens | |
1 | - |
1H,1H,2H,2H-perfluorodecyl sulfamate | pH 7.5, 20°C, HCA I | Homo sapiens |