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Literature summary for 4.2.1.1 extracted from
- Carbonic anhydrase and matrix metalloproteinase inhibitors: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes (2000), J. Med. Chem., 43, 3677-3687.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-4-methoxyphenylsulfonyl-N-2-nitrobenzyl-L-alanine hydroxamate | - |
Bos taurus |  |
| N-4-methoxyphenylsulfonyl-N-2-nitrobenzyl-L-alanine hydroxamate | - |
Homo sapiens | |
| N-4-methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate | - |
Bos taurus | |
| N-4-methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate | - |
Homo sapiens | |
| N-hydroxysulfonamide | - |
Bos taurus | |
| N-hydroxysulfonamide | - |
Homo sapiens | |
| N-n-perfluorobutylsulfonyl-alanine hydroxamate | - |
Bos taurus | |
| N-n-perfluorobutylsulfonyl-alanine hydroxamate | - |
Homo sapiens | |
| N-pentafluorophenylsulfonyl-glycine | - |
Bos taurus | |
| N-pentafluorophenylsulfonyl-glycine | - |
Homo sapiens | |
| N-pentafluorophenylsulfonyl-glycine hydroxamate | - |
Bos taurus | |
| N-pentafluorophenylsulfonyl-glycine hydroxamate | - |
Homo sapiens | |
| N-pentafluorophenylsulfonyl-N-4-nitrobenzyl-glycine hydroxamate | - |
Bos taurus | |
| N-pentafluorophenylsulfonyl-N-4-nitrobenzyl-glycine hydroxamate | - |
Homo sapiens | |
| sulfonamide | - |
Bos taurus | |
| sulfonamide | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc enzyme | Homo sapiens | |
| Zn2+ | zinc enzyme | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r | |
| H2CO3 | Bos taurus | - |
CO2 + H2O | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
| H2CO3 | - |
Bos taurus | CO2 + H2O | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bCA IV | - |
Bos taurus |
| CA I | - |
Homo sapiens |
| CA II | - |
Homo sapiens |
| CA IV | - |
Homo sapiens |
| CA IV | - |
Bos taurus |
| carbonic anhydrase | - |
Homo sapiens |
| carbonic anhydrase | - |
Bos taurus |
| hCA I | - |
Homo sapiens |
| HCA II | - |
Homo sapiens |
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