Literature summary for 4.2.1.1 extracted from

Iverson, T.M.; Alber, B.E.; Kisker, C.; Ferry, J.G.; Rees, D.C.
A closer look at the active site of gamma-class carbonic anhydrases: High resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila (2000), Biochemistry, 39, 9222-9231.

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Cloned(Commentary)

Cloned (Comment)	Organism
produced in Escherichia coli	Methanosarcina thermophila

Crystallization (Commentary)

Crystallization (Comment)	Organism
cubic crystals, space group P2(1)3, Zn-Cam, unit cell a : b : c: 82.64 A, Zn-Cam-HCO3-, unit cell a : b : c: 82.51 A, Zn-Cam-SO42-, unit cell a : b : c: 82.68 A, Co-Cam, unit cell a : b : c: 82.34 A, Co-Cam-HCO3-, unit cell a : b : c: 82.58 A, Co-Cam-SO42-, unit cell a : b : c: 82.61 A	Methanosarcina thermophila

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	can substitute for Zn2+	Methanosarcina thermophila
Zn2+	zinc-containing enzyme	Methanosarcina thermophila

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Methanosarcina thermophila	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Methanosarcina thermophila	P40881	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Methanosarcina thermophila

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Methanosarcina thermophila	CO2 + H2O	-	r

Synonyms

Synonyms	Comment	Organism
Cam	-	Methanosarcina thermophila
gamma-class carbonic anhydrase	-	Methanosarcina thermophila

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Release 2023.1 (January 2023)