Protein Variants | Comment | Organism |
---|---|---|
H200T | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
H67N | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
V62H/H67N/H200T | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
V62N | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
V62N/H67N | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-S-isobutylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | binds 800 times more strongly to carbonic anhydrase II than to carbonic anhydrase I | Homo sapiens | |
I- | inhibits 4-nitrophenyl acetate hydrolase activity | Homo sapiens | |
SCN- | inhibits 4-nitrophenyl acetate hydrolase activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.31 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
2.3 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N,H67N, H200T | Homo sapiens | |
2.4 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
2.4 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant H67B | Homo sapiens | |
2.8 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N62V | Homo sapiens | |
3.5 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
3.6 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
3.6 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
3.9 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant T200H | Homo sapiens | |
4 | - |
CO2 | pH 8.88, TAPS buffer, carbonic anhydrase I mutant V62N,H67N | Homo sapiens | |
5.3 | - |
CO2 | pH 8.77, 1,2-dimethylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
6.6 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
7.1 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
7.5 | - |
CO2 | pH 7.23, 1-methylimidazolebuffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
8.8 | - |
CO2 | pH 8.7, 1,2-dimethylimidazole buffer, carbonic anhydrase II | Homo sapiens | |
9.4 | - |
CO2 | pH 8.72, 1,2-dimethyimidazole buffer, carbonic anhydrase I mutant V62N,H67N | Homo sapiens | |
9.7 | - |
CO2 | pH 8.9, TAPS buffer, carbonic anhydrase II | Homo sapiens | |
10 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
14 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
14 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N67HV | Homo sapiens | |
15 | - |
CO2 | pH 7.23, 1-methylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
46 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
69 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
wild-type carbonic anhydrase I and active-site mutants V62N, H67N, H200T, double-mutant V62N,H67N, and triple-mutant V62H,H67N,H200T. Wild-type carbonic anhydrase II and active site mutant enzymes N62V, N67H and T200H | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
? | |
additional information | esterase activity with p-nitrophenyl acetate | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
85 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
117 | - |
CO2 | pH 6.3, MES buffer, wild-type carbonic anhydrase I | Homo sapiens | |
217 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
217 | - |
CO2 | pH 6.3, MES buffer | Homo sapiens | |
233 | - |
CO2 | pH 8.88, TAPS buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
250 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
433 | - |
CO2 | pH 8.8, TAPS buffer, wild-type carbonic anhydrase I | Homo sapiens | |
800 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
883 | - |
CO2 | pH 7.23, 1-methylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
1180 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N and carbonic anhydrase I mutant H67N | Homo sapiens | |
1380 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
1400 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
1470 | - |
CO2 | pH 8.88, TAPS buffer, carbonic anhydrase I mutant V62N,H67N | Homo sapiens | |
2000 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
2830 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
3500 | - |
CO2 | pH 8.77, 1,2-dimethylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
3500 | - |
CO2 | pH 8.72, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62B, H67B | Homo sapiens | |
3670 | - |
CO2 | pH 7.23, 1-methylimidazolebuffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4000 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant T200H | Homo sapiens | |
5500 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
8170 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N62V | Homo sapiens | |
8500 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
15200 | - |
CO2 | pH 8.7, 1,2-dimethylimidazole buffer, carbonic anhydrase II | Homo sapiens | |
16700 | - |
CO2 | pH 8.9, TAPS buffer, carbonic anhydrase II | Homo sapiens | |
28300 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N67H | Homo sapiens |