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Literature summary for 4.1.99.3 extracted from

  • Chaves, I.; Nijman, R.M.; Biernat, M.A.; Bajek, M.I.; Brand, K.; da Silva, A.C.; Saito, S.; Yagita, K.; Eker, A.P.; van der Horst, G.T.
    The potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock (2011), PLoS ONE, 6, e23447.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Potorous tridactylus
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Synonyms

Synonyms Comment Organism
CPD photolyase
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Potorous tridactylus

General Information

General Information Comment Organism
malfunction using transgenic mice expressing Potorous tridactylus CPD-photolyase, it is shown that Potorous CPD-photolyase affects the clock by shortening the period of behavioral rhythms. Constitutively expressed CPD-photolyase is shown to reduce the amplitude of circadian oscillations in cultured cells and to inhibit CLOCK/BMAL1 driven transcription by interacting with CLOCK. Potorous CPD-photolyase can restore the molecular oscillator in the liver of (clock-deficient) Cry1/Cry2 double knockout mice Potorous tridactylus