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Literature summary for 4.1.99.3 extracted from

  • Acocella, A.; Jones, G.A.; Zerbetto, F.
    What is adenine doing in photolyase? (2010), J. Phys. Chem. B, 114, 4101-4106.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
FADH2 two pathways for the electron transfer: the direct one, where the electron is transferred from the terminal methyl group of flavin to the carbonyl group of a thymine, and the indirect one, where the electron is ultimately transferred from the amino group of adenine to the carbonyl groups of the thymine dimer. Adenine in photolyase acts as an electrostatic bouncer that shoves the charge flow from flavin toward the DNA lesion that photolyase repairs. Electron transfer occurs from the flavin photolyase cofactor to the cyclobutane ring of DNA, previously formed by light-induced cycloaddition of adjacent pyrimidine bases Synechococcus elongatus PCC 7942 = FACHB-805

Organism

Organism UniProt Comment Textmining
Synechococcus elongatus PCC 7942 = FACHB-805
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Synonyms

Synonyms Comment Organism
DNA photolyase
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Synechococcus elongatus PCC 7942 = FACHB-805