Organism | UniProt | Comment | Textmining |
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Synechococcus elongatus PCC 7942 = FACHB-805 | - |
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Synonyms | Comment | Organism |
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photolyase | - |
Synechococcus elongatus PCC 7942 = FACHB-805 |
General Information | Comment | Organism |
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physiological function | photolyase can repair UV-damaged DNA in a mechanism requiring light and DNA base flipping, whereas cytochromes cannot repair DNA. Evolution of loop sequence likely plays a key role in functional diversification of cryptochromes and photolyases, through tuning of substrate recognition. Cryptochrome-DASH recognition loop peptide folds 2.5fold faster than its counterpart in photolyase, predominantly due to a lower enthalpy of activation. Binding duplex DNA in the catalytically-active base-flipped conformation imposes significant order on the recognition loop, and a corresponding entropic penalty, which may be surmounted by the more preorganized photolyase recognition loop, but may impose too large a barrier for the more dynamic loop in cryptochrome-DASH | Synechococcus elongatus PCC 7942 = FACHB-805 |