Protein Variants | Comment | Organism |
---|---|---|
additional information | by evolutionary sequence analysis it is shown that Met353 of the CPD photolyase derived from Anacystis nidulans is perfectly conserved throughout the putative class I CPD photolyase | Synechococcus elongatus PCC 7942 = FACHB-805 |
additional information | Met-353 of the CPD photolyase has been perfectly conserved throughout the putative class I CPD photolyases and plays a pivotal role in the biological function of DNA photolyase | Synechococcus elongatus PCC 7942 = FACHB-805 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Synechococcus elongatus PCC 7942 = FACHB-805 | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) | by molecular dynamics simulation and quantum mechanical calculations it is shown that indirect electron tunneling via the protein medium is as important as direct electron transfer from the donor (FADH-) to the acceptor (cyclobutane pyrimidine dimmer). At Met353 site busy electron tunneling traffic is observed. | Synechococcus elongatus PCC 7942 = FACHB-805 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclobutadipyrimidine in DNA | DNA photolyase recognizes ultraviolet-damaged DNA and breaks improperly formed covalent bonds within the cyclobutane pyrimidine dimer by a light-activated electron transfer reaction between FAD and cyclobutane pyrimidine dimer | Synechococcus elongatus PCC 7942 = FACHB-805 | pyrimidine residues in DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class I CPD photolyase | - |
Synechococcus elongatus PCC 7942 = FACHB-805 |
class I cyclobutane pyrimidine dimer photolyase | - |
Synechococcus elongatus PCC 7942 = FACHB-805 |
CPD photolyase | - |
Synechococcus elongatus PCC 7942 = FACHB-805 |
DNA photolyase | - |
Synechococcus elongatus PCC 7942 = FACHB-805 |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Synechococcus elongatus PCC 7942 = FACHB-805 | |
FADH2 | - |
Synechococcus elongatus PCC 7942 = FACHB-805 |