Activating Compound | Comment | Organism | Structure |
---|---|---|---|
FAD | enzyme contains FAD as catalytic cofactor and a second chromophore as a light harvesting antenna | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNA polymerase II | transcription by RNAPII and RNAPIII slows down the repair by photolyase on the transcribed strands | Saccharomyces cerevisiae | |
RNA polymerase III | transcription by RNAPII and RNAPIII slows down the repair by photolyase on the transcribed strands | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | major pathway to remove UV-induced DNA lesions from the genome | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
no activity in mammalia | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclobutadipyrimidine in DNA | - |
Saccharomyces cerevisiae | 2 pyrimidine residues in DNA | - |
? | |
cyclobutadipyrimidine in DNA | upon binding of DNA, the enzyme flips the pyrimidine dimer out of the duplex into a hole that contains the catalytic cofactor. The cyclobutane ring is then split by a light-initiated electron transfer reaction | Escherichia coli | 2 pyrimidine residues in DNA | - |
? | |
cyclobutadipyrimidine in nucleosome DNA | folding of DNA in nucleosomes efficiently protects DNA from being repaired | Escherichia coli | 2 pyrimidine residues in nucleosome DNA | - |
? | |
additional information | major pathway to remove UV-induced DNA lesions from the genome | Escherichia coli | ? | - |
? |