Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.99.19 extracted from

  • Martinez-Gomez, N.C.; Robers, M.; Downs, D.M.
    Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily (2004), J. Biol. Chem., 279, 40505-40510.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A26G the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
A272V the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
A373P the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
A50T the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
A51V the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
A61A the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
A61T the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
C285A the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
C285H the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
C89A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
D41V the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
D6E the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
E131A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
E131K the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
E187D the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
E29K the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
E55G the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
E55K the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
G130A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
G216C the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
G22V the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
G327C the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
h124Y the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
N87A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
N87K the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
P334Q the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
P347S the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
Q338L the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
R102P the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
R205W the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
T266N the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
V257A the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
V360I the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
W363C the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
Y190C the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
Y91A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium Q9S498
-
-

Synonyms

Synonyms Comment Organism
thiH
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
iron-sulfur centre contains an oxygen labile Fe-S cluster Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
physiological function the enzyme is required for the synthesis of the 4-methyl-5-hydroxyethyl-thiazole monophosphate moiety of thiamine diphosphate Salmonella enterica subsp. enterica serovar Typhimurium