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Literature summary for 4.1.99.14 extracted from

  • Chandra, T.; Silver, S.C.; Zilinskas, E.; Shepard, E.M.; Broderick, W.E.; Broderick, J.B.
    Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct (2009), J. Am. Chem. Soc., 131, 2420-2421.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Clostridium acetobutylicum

Metals/Ions

Metals/Ions Comment Organism Structure
Fe iron-sulfur enzyme, 2.9 Fe per enzyme Clostridium acetobutylicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine Clostridium acetobutylicum SPL repairs specifically the 5R isomer. (5''R)-alpha-5''(6''H)-bithymine is the diastereomer produced upon UV irradiation of a TpT dinucleotide thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine
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Organism

Organism UniProt Comment Textmining
Clostridium acetobutylicum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine SPL repairs specifically the 5R isomer. (5''R)-alpha-5''(6''H)-bithymine is the diastereomer produced upon UV irradiation of a TpT dinucleotide Clostridium acetobutylicum thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine
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(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine SPL repairs specifically the 5R isomer Clostridium acetobutylicum thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine
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Synonyms

Synonyms Comment Organism
SP lyase
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Clostridium acetobutylicum
SPL
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Clostridium acetobutylicum