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Literature summary for 4.1.99.13 extracted from

  • Yamamoto, J.; Hitomi, K.; Hayashi, R.; Getzoff, E.D.; Iwai, S.
    Recognition and reaction mechanisms of the (6-4) photolyase as determined by using a (6-4) photoproduct analog (2009), Nucleic Acids Symp. Ser., 53, 221-222.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Xenopus laevis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 2-thio analog of the the (6-4) photoproduct, in which the carbonyl group at the C2 of the 3'pyrimidone is replaced with a thiocarbonyl group, is not repaired by the (6-4) photolyase. Cationic imine analogue of the (6-4) photoproduct, in which the carbonyl group at the C2 of the 3'pyrimidone is replaced with an imine (T(6-4)TNH2), is not repaired by the (6-4) photolyase, even in the presence of a 10 molar excess of the enzyme. 3'carbonyl group of the (6-4) photoproduct is involved in the recognition and reaction of the (6-4) photolyse Xenopus laevis ?
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T(6-4)T photoproduct (in DNA)
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Xenopus laevis 2 thymidine residues (in DNA)
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?

Synonyms

Synonyms Comment Organism
(6-4) photolyase
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Xenopus laevis