Protein Variants | Comment | Organism |
---|---|---|
H463F | site-directed mutagenesis, the mutant shows very low activity for elimination of indole but is still competent to form a quinonoid intermediate from L-tryptophan, pH dependence of quinonoid intermediate formation, overview | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of mutant H463F, high-pressure stopped-flow measurements, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + H2O | Escherichia coli | - |
indole + pyruvate + NH3 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-tryptophan + H2O = indole + pyruvate + NH3 | quinonoid intermediate formation involving Tyr71 and Cys298, mechanism, active site preorganization, overview | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + H2O | - |
Escherichia coli | indole + pyruvate + NH3 | - |
r | |
L-tryptophan + H2O | reversible hydrolytic beta-elimination | Escherichia coli | indole + pyruvate + NH3 | - |
r | |
S-(2-nitrophenyl)-L-cysteine + H2O | - |
Escherichia coli | ? | - |
r |
Synonyms | Comment | Organism |
---|---|---|
TIL | - |
Escherichia coli |
tryptophan indole-lyase | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Escherichia coli |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9.5 | pH dependence of quinonoid intermediate formation, overview | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Escherichia coli |