Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D204N | reduced catalytic efficiency, mutation causes 3-hydroxy-3-methylgluratic aciduria in vivo | Homo sapiens |
S201Y | no catalytic efficiency, mutation causes 3-hydroxy-3-methylgluratic aciduria in vivo | Homo sapiens |
S75R | no catalytic efficiency, mutation causes 3-hydroxy-3-methylgluratic aciduria in vivo | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.1 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | 37°C, pH 7.5, wild type | Homo sapiens | |
6.6 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | 37°C, pH 7.5, D204N mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | last step in ketogenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-Hydroxy-3-methylglutaryl-CoA | - |
Homo sapiens | Acetyl-CoA + acetoacetate | - |
? | |
additional information | last step in ketogenesis | Homo sapiens | ? | - |
? |