Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D42A | 4fold decrease in proton exchange | Homo sapiens |
H233A | 10fold decrease in proton exchange | Homo sapiens |
R41M | lower activity than R41Q mutant | Homo sapiens |
R41Q | mutation leads to human HMG-CoA lyase deficiency | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetoacetate | - |
Homo sapiens | |
acetyldithio-CoA | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
48 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | wild-type | Homo sapiens | |
62 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | R41Q mutant | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required, Km wild-type enzyme: 0.2mM, Km R41Q mutant: 0.088 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | last step in ketogenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-Hydroxy-3-methylglutaryl-CoA | - |
Homo sapiens | Acetyl-CoA + acetoacetate | - |
? | |
additional information | last step in ketogenesis | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | R41Q mutant | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.021 | - |
acetoacetate | - |
Homo sapiens | |
0.17 | - |
acetyldithio-CoA | - |
Homo sapiens |