Literature summary for 4.1.3.4 extracted from

Mitchell, G.A.; Robert, M.F.; Hruz, P.W.; Wang, S.; Fontaine, G.; Behnke, C.E.; Mende-Mueller, L.M.; Schappert, K.; Lee, C.; Gibson, K.M.; Miziorko, H.M.
3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL) (1993), J. Biol. Chem., 268, 4376-4381.

Search for more literature for 4.1.3.4

Application

Application	Comment	Organism
medicine	genetically heterogeneous deficiency, participation of S69 codon 2-base pair deletion in some cases	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
nucleotide sequence	Gallus gallus
nucleotide sequence, identification of a 2-base pair deletion in S69 codon of enzyme-deficient patients	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	matrix	Gallus gallus	5739	-
mitochondrion	matrix	Homo sapiens	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
31600	-	x * 31600, estimated from nucleotide sequence	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	chicken	-
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate	identification of functionally important S69	Homo sapiens	a

Source Tissue

Source Tissue	Comment	Organism	Textmining

Subunits

Subunits	Comment	Organism
?	x * 31600, estimated from nucleotide sequence	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)