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Literature summary for 4.1.3.30 extracted from
- Probing the catalytic mechanism involved in the isocitrate lyase superfamily hybrid quantum mechanical/molecular mechanical calculations on 2,3-dimethylmalate lyase (2015), J. Phys. Chem. B, 119, 11473-11484 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C123S | the mutation has a significant effect on its mechanism in terms of both rate and stereochemistry | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate | Mycobacterium tuberculosis | - |
succinate + pyruvate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate | - |
Mycobacterium tuberculosis | succinate + pyruvate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-Methylisocitrate lyase | - |
Mycobacterium tuberculosis |
| MICL | - |
Mycobacterium tuberculosis |
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