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Literature summary for 4.1.3.30 extracted from

  • Brock, M.
    Generation and phenotypic characterization of Aspergillus nidulans methylisocitrate lyase deletion mutants: methylisocitrate inhibits growth and conidiation (2005), Appl. Environ. Microbiol., 71, 5465-5475.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate Aspergillus nidulans one of the key enzymes of the methylcitrate cycle. Deletion mutants do not grow on propionate as sole carbon and energy source and are severely inhibited during growth on alternative carbon sources, when propionate is present. The strongest inhibitory effect is observed, when glycerol is the main carbon source, followed by glucose and acetate. In addition, asexual conidiation is strongly impaired in the presence of propionate Pyruvate + succinate
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Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
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Purification (Commentary)

Purification (Comment) Organism
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Aspergillus nidulans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate one of the key enzymes of the methylcitrate cycle. Deletion mutants do not grow on propionate as sole carbon and energy source and are severely inhibited during growth on alternative carbon sources, when propionate is present. The strongest inhibitory effect is observed, when glycerol is the main carbon source, followed by glucose and acetate. In addition, asexual conidiation is strongly impaired in the presence of propionate Aspergillus nidulans Pyruvate + succinate
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(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate the enzyme is highly specific for (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate Aspergillus nidulans Pyruvate + succinate
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