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Literature summary for 4.1.3.27 extracted from
- Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium (1968), Biochemistry, 7, 3566-3573.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium |  |
| Bromopyruvate | inactivation prevented by chorismate and Trp | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Diethylamine | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Dimethylamine | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Gln | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Glu | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| L-Trp | competitive with chorismate, noncompetitive with NH4+, reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| methylamine | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| N-Methylhydroxylamine | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| NEM | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| PCMB | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| pyruvate | competitive with respect to chorismate, noncompetitive with respect to NH4+, reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| trimethylamine | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
chorismate | reaction of component I, with NH4+ as cosubstrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 24 | - |
NH4+ | reaction of component I | Salmonella enterica subsp. enterica serovar Typhimurium | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Mg2+ | reaction of component I with NH4+ as substrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| component I | Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.384 | - |
activity of component I | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate + L-Gln | component I is inactive with L-Gln | Salmonella enterica subsp. enterica serovar Typhimurium | anthranilate + pyruvate + L-glutamate | - |
? | |
| chorismate + NH4+ | reaction is catalyzed by component I alone and in combination with component II | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | component I has a MW of 63000 Da, gel filtration | Salmonella enterica subsp. enterica serovar Typhimurium |
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