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Literature summary for 4.1.3.16 extracted from

  • MacDonald, J.R.; Huang, A.D.; Loomes, K.M.
    Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3 (2016), FEBS Lett., 590, 1467-1476 .
    View publication on PubMed
Search for more literature for 4.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) cells and HEK-293 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-Hydroxy-2-oxoglutarate Homo sapiens
-
 Pyruvate + glyoxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86XE5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-Hydroxy-2-oxoglutarate
-
 Homo sapiens Pyruvate + glyoxylate
-
 ?

Subunits

Subunits Comment Organism
? x * 32466, mass spectrometry Homo sapiens

Synonyms

Synonyms Comment Organism
HOGA1
-
 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
68
-
 melting temperature Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme mutations ultimately lead to oxalate accumulation and stone formation in primary hyperoxaluria type 3 Homo sapiens