Literature summary for 4.1.2.9 extracted from

Henard, C.A.; Freed, E.F.; Guarnieri, M.T.
Phosphoketolase pathway engineering for carbon-efficient biocatalysis (2015), Curr. Opin. Biotechnol., 36, 183-188 .

Search for more literature for 4.1.2.9

Application

Application	Comment	Organism
biotechnology	pathway engineering advances in a high-potential alternative route, the phosphoketolase pathway, which facilitates bypass of pyruvate decarboxylation and enables complete carbon conservation in bioprocesses targeting pentose phosphate pathway and/or acetyl-CoA-derived products	Bifidobacterium animalis subsp. lactis

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of the Bifidobacterium animalis xfp gene (encoding a phosphoketolase with dual substrate specificity) in a Corynebacterium glutamicum strain that is previously engineered to overproduce L-glutamic acid results in a 14% increase in the L-Glu yield from glucose	Bifidobacterium animalis subsp. lactis

Organism

Organism	UniProt	Comment	Textmining
Bifidobacterium animalis subsp. lactis	Q9AEM9	-	-
Bifidobacterium animalis subsp. lactis DSM 101403	Q9AEM9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Fructose 6-phosphate + phosphate	the bifunctional enzyme shows activity with D-fructose 6-phosphate and D-xylulose 5-phosphate. It displays substantially higher preference for D-xylulose 5-phosphate than for D-fructose 6-phosphate	Bifidobacterium animalis subsp. lactis	Acetyl phosphate + D-erythrose 4-phosphate + H2O	-	?
D-Fructose 6-phosphate + phosphate	the bifunctional enzyme shows activity with D-fructose 6-phosphate and D-xylulose 5-phosphate. It displays substantially higher preference for D-xylulose 5-phosphate than for D-fructose 6-phosphate	Bifidobacterium animalis subsp. lactis DSM 101403	Acetyl phosphate + D-erythrose 4-phosphate + H2O	-	?
D-Xylulose 5-phosphate + phosphate	the bifunctional enzyme shows activity with D-fructose 6-phosphate and D-xylulose 5-phosphate. It displays substantially higher preference for D-xylulose 5-phosphate than for D-fructose 6-phosphate	Bifidobacterium animalis subsp. lactis	Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O	-	?
D-Xylulose 5-phosphate + phosphate	the bifunctional enzyme shows activity with D-fructose 6-phosphate and D-xylulose 5-phosphate. It displays substantially higher preference for D-xylulose 5-phosphate than for D-fructose 6-phosphate	Bifidobacterium animalis subsp. lactis DSM 101403	Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O	-	?

Synonyms

Synonyms	Comment	Organism
Xfp	-	Bifidobacterium animalis subsp. lactis

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Release 2023.1 (January 2023)