Literature summary for 4.1.2.8 extracted from

Barends, T.R.; Dunn, M.F.; Schlichting, I.
Tryptophan synthase, an allosteric molecular factory (2008), Curr. Opin. Chem. Biol., 12, 593-600.

Search for more literature for 4.1.2.8

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

Protein Variants	Comment	Organism
Q114N	betaGln114Asn mutation, which shortens the betaGln114 side chain connecting the betaL3 loop with the rest of the protein, resulted in two fractions of enzyme	Salmonella enterica subsp. enterica serovar Typhimurium
Y110V	betaThr110Val mutation, which replaces a hydrogen bonding partner to the substrate carboxylate with a methyl group severely decreased the ability to form the aminoacrylate external aldimine E(AA) and consequently severely impaired beta-reaction and alphabeta-reaction	Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
indole-3-glycerol phosphate	alpha-site cleaves the C3-C30 bond of IGP	Salmonella enterica subsp. enterica serovar Typhimurium	indole + D-glyceraldehyde 3-phosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	TrpS alphabeta-dimer	Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms	Comment	Organism
TRPS	-	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)