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Literature summary for 4.1.2.50 extracted from
- Biochemical and structural studies of 6-carboxy-5,6,7,8-tetrahydropterin synthase reveal the molecular basis of catalytic promiscuity within the tunnel-fold superfamily (2014), J. Biol. Chem., 289, 23641-23652 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging drop vapor diffusion method, using 5% (v/v) 2-methyl-1,3-propanediol, 0.04 M CaCl2, 0.1 M sodium acetate (pH 4.5) | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C27A | inactive | Escherichia coli |
| D70N/H71A | the mutant shows greatly reduced activity compared to the wild type enzyme | Escherichia coli |
| H25A/D54N | inactive | Escherichia coli |
| H25A/D54N/D70N/H71A | inactive | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | contains a catalytic zinc ion | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydroneopterin 3'-triphosphate + H2O | Escherichia coli | - |
6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P65870 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydroneopterin 3'-triphosphate + H2O | - |
Escherichia coli | 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | - |
? | |
| sepiapterin + H2O | - |
Escherichia coli | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homohexamer | - |
Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-carboxy-5,6,7,8-tetrahydropterin synthase | - |
Escherichia coli |
| 6-pyruvoyltetrahydropterin synthase | - |
Escherichia coli |
| CPH4 synthase | - |
Escherichia coli |
| PTPS | - |
Escherichia coli |
| QueD | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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