Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene queD | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | reaction mechanism, overview | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-pyruvoyltetrahydropterin + H2O | - |
Escherichia coli | 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | - |
? | |
7,8-dihydroneopterin triphosphate + H2O | - |
Escherichia coli | 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | - |
? | |
additional information | 6-pyruvoyltetrahydropterin can tautomerize to sepiapterin, the hydrate of which undergoes carbon-carbon bond cleavage by an aldolase-like mechanism, followed by a tautomerization, to yield 6-carboxy-5,6,7,8-tetrahydropterin | Escherichia coli | ? | - |
? | |
sepiapterin + H2O | - |
Escherichia coli | 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-carboxy-5,6,7,8-tetrahydropterin synthase | - |
Escherichia coli |
QueD | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | QueD catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-carboxy-5,6,7,8-tetrahydropterin, CPH4. QueD can also convert 6-pyruvoyltetrahydropterin, PPH4, and sepiapterin to CPH4 | Escherichia coli |