Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.2.48 extracted from

  • Gwon, H.J.; Baik, S.H.
    Diastereoselective synthesis of L-threo-3,4-dihydroxyphenylserine by low-specific L-threonine aldolase mutants (2010), Biotechnol. Lett., 32, 143-149.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
R241C/A287V the mutations dramatically increase the diastereoselectivity of the reverse aldol condensation activity for L-threo-3,4-dihydroxyphenylserine Streptomyces coelicolor
V86I/R241C/Y306C the mutations dramatically increase the diastereoselectivity of the reverse aldol condensation activity for L-threo-3,4-dihydroxyphenylserine Streptomyces coelicolor
Y34C the mutation dramatically increases the diastereoselectivity of the reverse aldol condensation activity for L-threo-3,4-dihydroxyphenylserine Streptomyces coelicolor
Y39C/Y306C the mutations dramatically increase the diastereoselectivity of the reverse aldol condensation activity for L-threo-3,4-dihydroxyphenylserine Streptomyces coelicolor
Y39C/Y306C/A48T the mutations dramatically increase the diastereoselectivity of the reverse aldol condensation activity for L-threo-3,4-dihydroxyphenylserine Streptomyces coelicolor
Y39C/Y306C/R316C the mutations dramatically increase the diastereoselectivity of the reverse aldol condensation activity for L-threo-3,4-dihydroxyphenylserine Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Thr Streptomyces coelicolor
-
glycine + acetaldehyde
-
?
L-Thr Streptomyces coelicolor A3(2)
-
glycine + acetaldehyde
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
-
-
-
Streptomyces coelicolor A3(2)
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + 3,4-dihydroxybenzaldehyde
-
Streptomyces coelicolor L-threo-3,4-dihydroxyphenylserine + L-erythro-3,4-dihydroxyphenylserine
-
r
glycine + 3,4-dihydroxybenzaldehyde
-
Streptomyces coelicolor A3(2) L-threo-3,4-dihydroxyphenylserine + L-erythro-3,4-dihydroxyphenylserine
-
r
L-Thr
-
Streptomyces coelicolor glycine + acetaldehyde
-
?
L-Thr
-
Streptomyces coelicolor A3(2) glycine + acetaldehyde
-
?

Synonyms

Synonyms Comment Organism
L-TA
-
Streptomyces coelicolor
L-threonine aldolase
-
Streptomyces coelicolor

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Streptomyces coelicolor