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Literature summary for 4.1.2.43 extracted from
- Genomic organization and biochemistry of the ribulose monophosphate pathway and its application in biotechnology (2009), Appl. Microbiol. Biotechnol., 84, 407-416.
Application
| Application | Comment | Organism |
|---|---|---|
| environmental protection | formaldehyde is thought to be the cause of sick house syndrome, transgenic plants harboring the ribulose monophosphate pathway could be useful to improve air pollution in the indoor environment | Mycobacterium gastri |
| synthesis | enzymatic preparation is suitable for the synthesis of sugars labeled with 13C at specific positions, enzymatic preparation of [1-13C]D-fructose-6-phosphate by using D-ribose-5 phosphate and [1-13C]-formaldehyde as substrates | Methylomonas aminofaciens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Pyrococcus |
| expression in Escherichia coli | Methanosarcina sp. |
| expression in Escherichia coli | Thermococcus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | in order to improve the rate of vanillin degradation by Burkholderia cepacia TM1, the hps and phi genes from Methylomonas aminofaciens 77a are heterologously expressed in strain TM1, the transformant strain constitutively produces active 3-hexulose-6-phosphate synthase and 6-phospho-3-hexuloisomerase enzymes and the degradation of vanillic acid and the growth yield are significantly improved | Methylomonas aminofaciens |
| additional information | the hps and phi genes from the methylotrophic bacterium Mycobacterium gastri MB19 are introduced into tobacco. Both genes are expressed under the control of the tomato rbcS-3C promoter, and the gene products are targeted to the chloroplasts by artificially added transit peptide sequence, the expression of both genes in plants enhances the tolerance of the transgenic plant to formaldehyde and capability of eliminating environmental formaldehyde | Mycobacterium gastri |
| additional information | the solvent-tolerant bacterium, Pseudomonas putida S12, is engineered to efficiently utilize methanol and formaldehyde as auxiliary substrates by introducing the hps and phi genes from the thermotolerant methylotrophic bacterium Bacillus brevis, by chemostat culture experiments using glucose and formaldehyde, the hps and phi-expressing strain shows both significantly improved cell mass and growth at higher formaldehyde concentrations than the control strain | Brevibacillus brevis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Brevibacillus brevis |  |
| Mg2+ | - |
Bacillus subtilis | |
| Mg2+ | - |
Bacillus sp. (in: Bacteria) | |
| Mg2+ | - |
Methylococcus capsulatus | |
| Mg2+ | - |
Bacillus methanolicus | |
| Mg2+ | - |
Methanocaldococcus jannaschii | |
| Mg2+ | - |
Methylobacillus flagellatus | |
| Mg2+ | - |
Thermococcus kodakarensis | |
| Mg2+ | - |
Pyrococcus | |
| Mg2+ | - |
Methanosarcina sp. | |
| Mg2+ | - |
Methylomonas aminofaciens | |
| Mg2+ | - |
Mycobacterium gastri | |
| Mg2+ | - |
Salmonella | |
| Mg2+ | - |
Thermococcus | |
| Mg2+ | - |
Methanococcus | |
| Mg2+ | - |
Staphylococcus | |
| Mn2+ | - |
Brevibacillus brevis | |
| Mn2+ | - |
Bacillus subtilis | |
| Mn2+ | - |
Bacillus sp. (in: Bacteria) | |
| Mn2+ | - |
Methylococcus capsulatus | |
| Mn2+ | - |
Bacillus methanolicus | |
| Mn2+ | - |
Methanocaldococcus jannaschii | |
| Mn2+ | - |
Methylobacillus flagellatus | |
| Mn2+ | - |
Thermococcus kodakarensis | |
| Mn2+ | - |
Pyrococcus | |
| Mn2+ | - |
Methanosarcina sp. | |
| Mn2+ | - |
Methylomonas aminofaciens | |
| Mn2+ | - |
Mycobacterium gastri | |
| Mn2+ | - |
Salmonella | |
| Mn2+ | - |
Thermococcus | |
| Mn2+ | - |
Methanococcus | |
| Mn2+ | - |
Staphylococcus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-ribulose 5-phosphate + formaldehyde | Brevibacillus brevis | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Bacillus subtilis | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Bacillus sp. (in: Bacteria) | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methylococcus capsulatus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Bacillus methanolicus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methanocaldococcus jannaschii | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methylobacillus flagellatus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Thermococcus kodakarensis | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Pyrococcus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methanosarcina sp. | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methylomonas aminofaciens | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Mycobacterium gastri | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Salmonella | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Thermococcus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methanococcus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Staphylococcus | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Pyrococcus horikoshii | the apparent specific activity of the reverse reaction is approximately one-seventh of that of the forward reaction | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Brevibacillus brevis S1 | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Mycobacterium gastri MB19 | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Methylomonas aminofaciens 77a | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | Bacillus methanolicus MGA3 | - |
D-arabino-3-hexulose 6-phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus methanolicus | - |
- |
- |
| Bacillus methanolicus MGA3 | - |
- |
- |
| Bacillus sp. (in: Bacteria) | - |
- |
- |
| Bacillus subtilis | - |
- |
- |
| Brevibacillus brevis | - |
- |
- |
| Brevibacillus brevis S1 | - |
- |
- |
| Methanocaldococcus jannaschii | - |
- |
- |
| Methanococcus | - |
- |
- |
| Methanosarcina sp. | - |
- |
- |
| Methylobacillus flagellatus | - |
obligate methylotroph | - |
| Methylococcus capsulatus | - |
- |
- |
| Methylomonas aminofaciens | - |
- |
- |
| Methylomonas aminofaciens 77a | - |
- |
- |
| Mycobacterium gastri | - |
facultative methylotroph | - |
| Mycobacterium gastri MB19 | - |
facultative methylotroph | - |
| Pyrococcus | - |
- |
- |
| Pyrococcus horikoshii | - |
- |
- |
| Salmonella | - |
- |
- |
| Staphylococcus | - |
- |
- |
| Thermococcus | - |
- |
- |
| Thermococcus kodakarensis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-ribulose 5-phosphate + formaldehyde | - |
Brevibacillus brevis | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Bacillus subtilis | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Bacillus sp. (in: Bacteria) | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methylococcus capsulatus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Bacillus methanolicus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methanocaldococcus jannaschii | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methylobacillus flagellatus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Thermococcus kodakarensis | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Pyrococcus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methanosarcina sp. | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methylomonas aminofaciens | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Mycobacterium gastri | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Salmonella | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Thermococcus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methanococcus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Staphylococcus | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | the apparent specific activity of the reverse reaction is approximately one-seventh of that of the forward reaction | Pyrococcus horikoshii | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Brevibacillus brevis S1 | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Mycobacterium gastri MB19 | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Methylomonas aminofaciens 77a | D-arabino-3-hexulose 6-phosphate | - |
r | |
| D-ribulose 5-phosphate + formaldehyde | - |
Bacillus methanolicus MGA3 | D-arabino-3-hexulose 6-phosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-hexulose-6-phosphate synthase | - |
Brevibacillus brevis |
| 3-hexulose-6-phosphate synthase | - |
Bacillus subtilis |
| 3-hexulose-6-phosphate synthase | - |
Bacillus sp. (in: Bacteria) |
| 3-hexulose-6-phosphate synthase | - |
Methylococcus capsulatus |
| 3-hexulose-6-phosphate synthase | - |
Bacillus methanolicus |
| 3-hexulose-6-phosphate synthase | - |
Methanocaldococcus jannaschii |
| 3-hexulose-6-phosphate synthase | - |
Pyrococcus horikoshii |
| 3-hexulose-6-phosphate synthase | - |
Methylobacillus flagellatus |
| 3-hexulose-6-phosphate synthase | - |
Thermococcus kodakarensis |
| 3-hexulose-6-phosphate synthase | - |
Pyrococcus |
| 3-hexulose-6-phosphate synthase | - |
Methanosarcina sp. |
| 3-hexulose-6-phosphate synthase | - |
Methylomonas aminofaciens |
| 3-hexulose-6-phosphate synthase | - |
Mycobacterium gastri |
| 3-hexulose-6-phosphate synthase | - |
Salmonella |
| 3-hexulose-6-phosphate synthase | - |
Thermococcus |
| 3-hexulose-6-phosphate synthase | - |
Methanococcus |
| 3-hexulose-6-phosphate synthase | - |
Staphylococcus |
| HPS | - |
Brevibacillus brevis |
| HPS | - |
Bacillus subtilis |
| HPS | - |
Bacillus sp. (in: Bacteria) |
| HPS | - |
Methylococcus capsulatus |
| HPS | - |
Bacillus methanolicus |
| HPS | - |
Methanocaldococcus jannaschii |
| HPS | - |
Pyrococcus horikoshii |
| HPS | - |
Methylobacillus flagellatus |
| HPS | - |
Thermococcus kodakarensis |
| HPS | - |
Pyrococcus |
| HPS | - |
Methanosarcina sp. |
| HPS | - |
Methylomonas aminofaciens |
| HPS | - |
Mycobacterium gastri |
| HPS | - |
Salmonella |
| HPS | - |
Thermococcus |
| HPS | - |
Methanococcus |
| HPS | - |
Staphylococcus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | phylogenetic analysis | Brevibacillus brevis |
| evolution | phylogenetic analysis | Bacillus subtilis |
| evolution | phylogenetic analysis | Bacillus sp. (in: Bacteria) |
| evolution | phylogenetic analysis | Methylococcus capsulatus |
| evolution | phylogenetic analysis | Bacillus methanolicus |
| evolution | phylogenetic analysis | Methanocaldococcus jannaschii |
| evolution | phylogenetic analysis | Pyrococcus horikoshii |
| evolution | phylogenetic analysis | Methylobacillus flagellatus |
| evolution | phylogenetic analysis | Thermococcus kodakarensis |
| evolution | phylogenetic analysis | Pyrococcus |
| evolution | phylogenetic analysis | Methanosarcina sp. |
| evolution | phylogenetic analysis | Methylomonas aminofaciens |
| evolution | phylogenetic analysis | Mycobacterium gastri |
| evolution | phylogenetic analysis | Salmonella |
| evolution | phylogenetic analysis | Thermococcus |
| evolution | phylogenetic analysis | Methanococcus |
| evolution | phylogenetic analysis | Staphylococcus |
| physiological function | bifunctional enzyme | Pyrococcus horikoshii |
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