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Literature summary for 4.1.2.42 extracted from

  • Liu, J.Q.; Odani, M.; Yasuoka, T.; Dairi, T.; Itoh, N.; Kataoka, M.; Shimizu, S.; Yamada, H.
    Gene cloning and overproduction of low-specificity D-threonine aldolase from Alcaligenes xylosoxidans and its application for production of a key intermediate for parkinsonism drug (2000), Appl. Microbiol. Biotechnol., 54, 44-51.
    View publication on PubMed
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Application

Application Comment Organism
medicine efficient biocatalyst for resolution of L-X-3,4-methylenedioxyphenylserine, an intermediate for production of a therapeutic drug for Parkinson's disease Achromobacter xylosoxidans

Cloned(Commentary)

Cloned (Comment) Organism
-
 Achromobacter xylosoxidans

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-threonine Achromobacter xylosoxidans
-
 glycine + acetaldehyde
-
 r

Organism

Organism UniProt Comment Textmining
Achromobacter xylosoxidans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
homogeneity Achromobacter xylosoxidans

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
38.6
-
-
 Achromobacter xylosoxidans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-threonine
-
 Achromobacter xylosoxidans glycine + acetaldehyde
-
 ?
D-threonine
-
 Achromobacter xylosoxidans glycine + acetaldehyde
-
 r

Synonyms

Synonyms Comment Organism
low specificity D-TA acts on the D-isomer Achromobacter xylosoxidans

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent Achromobacter xylosoxidans