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Literature summary for 4.1.2.4 extracted from
- DNA vaccination with a gene encoding Toxoplasma gondii deoxyribose phosphate aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice (2014), Parasit. Vectors, 7, 431 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | possible selection as a vaccine candidate. The purified recombinant protein is used to immunize rats. The antibodies obtained are used to verify in vitro expression of the enzyme. The vector pVAX1 is utilized to formulate a DNA vaccine designated as pTgDPA, which is used to evaluate the immunological changes and the level of protection against challenge with the virulent RH strain of Toxoplasma gondii. DNA vaccine, TgDPA revealed that it can induce a strong humoral as well as cellular mediated response in mice. These responses are a contribution of TH1, TH2 and TH17 type of responses. Mice immunized with TgDPA show longer survival rates than do mice in control groups | Toxoplasma gondii |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Toxoplasma gondii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Toxoplasma gondii | - |
- |
- |
| Toxoplasma gondii RH | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein | Toxoplasma gondii |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| tachyzoite | - |
Toxoplasma gondii | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TgDPA | - |
Toxoplasma gondii |
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