Literature summary for 4.1.2.4 extracted from

Zhang, S.; Bisterfeld, C.; Bramski, J.; Vanparijs, N.; De Geest, B.G.; Pietruszka, J.; Boeker, A.; Reinicke, S.
Biocatalytically active thin films via self-assembly of 2-deoxy-D-ribose-5-phosphate aldolase-poly(N-isopropylacrylamide) conjugates (2018), Bioconjug. Chem., 29, 104-116 .

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Application

Application	Comment	Organism
synthesis	industrial application of the enzyme for the synthesis of a key building block for the pharmaceutical blockbuster atorvastatin. The main drawback of the enzyme being used in such a process is its sensitivity to industrially relevant concentrations of the substrate and the occurrence of product inhibition. Product inhibition can be avoided by coupling the catalytic transformation with transport processes, which, in turn, would require an immobilization of the enzyme within a thin film that can be deposited on a membrane support. A fabrication process for such films is developed that is based on the formation of DERA-poly(N-isopropylacrylamide) conjugates that are subsequently allowed to self-assemble at an air-water interface to yield the respective film	Escherichia coli

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Synonyms

Synonyms	Comment	Organism
2-deoxy-D-ribose-5-phosphate aldolase	-	Escherichia coli
DERA	-	Escherichia coli

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Release 2023.1 (January 2023)