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Literature summary for 4.1.2.27 extracted from

  • Abu Khweek, A.; Kanneganti, A.; Guttridge D, D.C.; Amer, A.O.
    The sphingosine-1-phosphate lyase (LegS2) contributes to the restriction of Legionella pneumophila in murine macrophages (2016), PLoS ONE, 11, e0146410 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Legionella pneumophila
-
 phosphoethanolamine + palmitaldehyde
-
 ?
sphinganine 1-phosphate Legionella pneumophila JR32
-
 phosphoethanolamine + palmitaldehyde
-
 ?

Organism

Organism UniProt Comment Textmining
Legionella pneumophila
-
-
-
Legionella pneumophila JR32
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
 Legionella pneumophila phosphoethanolamine + palmitaldehyde
-
 ?
sphinganine 1-phosphate
-
 Legionella pneumophila JR32 phosphoethanolamine + palmitaldehyde
-
 ?

Synonyms

Synonyms Comment Organism
LegS2
-
 Legionella pneumophila
SPL
-
 Legionella pneumophila

General Information

General Information Comment Organism
malfunction the absence of the enzyme is associated with reduced NF-kappaB activation and atypical morphology of mitochondria Legionella pneumophila