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Literature summary for 4.1.2.27 extracted from

  • Ohtoyo, M.; Tamura, M.; Machinaga, N.; Muro, F.; Hashimoto, R.
    Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency (2015), Mol. Cell. Biochem., 400, 125-133 .
    View publication on PubMed
Search for more literature for 4.1.2.27

Inhibitors

Inhibitors Comment Organism Structure
2-acetyl-4-(tetrahydroxybutyl)imidazole the enzyme is inhibited indirectly by 2-acetyl-4-(tetrahydroxybutyl)imidazole under conditions of vitamin B6 deficiency Mus musculus
4-deoxypyridoxine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Mus musculus
-
 phosphoethanolamine + palmitaldehyde
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IT-79MTNC3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
 Mus musculus phosphoethanolamine + palmitaldehyde
-
 ?

Synonyms

Synonyms Comment Organism
sphingosine 1-phosphate lyase
-
 Mus musculus
SPL
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus