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Literature summary for 4.1.2.27 extracted from

  • Hahn, C.; Tyka, K.; Saba, J.D.; Lenzen, S.; Gurgul-Convey, E.
    Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity (2017), J. Biol. Chem., 292, 20292-20304 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Rattus norvegicus
-
 phosphoethanolamine + palmitaldehyde
-
 ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
INS-1E cell
-
 Rattus norvegicus
-
intestine
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
pancreas
-
 Rattus norvegicus
-
pancreatic islet
-
 Rattus norvegicus
-
skeletal muscle
-
 Rattus norvegicus
-
spleen
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
 Rattus norvegicus phosphoethanolamine + palmitaldehyde
-
 ir

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
S1P lyase
-
 Rattus norvegicus
sphingosine-1-phosphate lyase
-
 Rattus norvegicus
SPL
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function enzyme overexpression reduces cytokine-induced endoplasmic reticulum stress, regulates Ca2+ homeostasis and Bcl2-associated death promotor phosphorylation in INS1E cells, and protects against cytokine-mediated inhibition of cell proliferation and caspase-3 activation in insulin-secreting INS1E cells Rattus norvegicus