Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.2.27 extracted from

  • Sanllehi, P.; Abad, J.L.; Bujons, J.; Casas, J.; Delgado, A.
    Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates (2016), Eur. J. Med. Chem., 123, 905-915 .
    View publication on PubMed
Search for more literature for 4.1.2.27

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
1-deoxysphinganine 1-phosphonate
-
 Homo sapiens
1-deoxysphinganine 1-phosphonate
-
 Symbiobacterium thermophilum
2-vinyldihydrosphingosine 1-phosphate
-
 Homo sapiens
2-vinyldihydrosphingosine 1-phosphate
-
 Symbiobacterium thermophilum
4-deoxypyridoxine
-
 Homo sapiens
4-deoxypyridoxine
-
 Symbiobacterium thermophilum
FTY720
-
 Homo sapiens
FTY720
-
 Symbiobacterium thermophilum
phosphopyridoxyl sphinganine 1-phosphate
-
 Homo sapiens
phosphopyridoxyl sphinganine 1-phosphate
-
 Symbiobacterium thermophilum
phosphopyridoxyl sphingosine 1-phosphate
-
 Homo sapiens
phosphopyridoxyl sphingosine 1-phosphate
-
 Symbiobacterium thermophilum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Homo sapiens
-
 phosphoethanolamine + palmitaldehyde
-
 ir
sphinganine 1-phosphate Symbiobacterium thermophilum
-
 phosphoethanolamine + palmitaldehyde
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Symbiobacterium thermophilum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RBM13
-
 Homo sapiens ?
-
 ?
RBM13
-
 Symbiobacterium thermophilum ?
-
 ?
sphinganine 1-phosphate
-
 Homo sapiens phosphoethanolamine + palmitaldehyde
-
 ir
sphinganine 1-phosphate
-
 Symbiobacterium thermophilum phosphoethanolamine + palmitaldehyde
-
 ir

Synonyms

Synonyms Comment Organism
S1PL
-
 Homo sapiens
S1PL
-
 Symbiobacterium thermophilum
sphingosine-1-phosphate lyase
-
 Homo sapiens
sphingosine-1-phosphate lyase
-
 Symbiobacterium thermophilum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens
pyridoxal 5'-phosphate
-
 Symbiobacterium thermophilum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
 1-deoxysphinganine 1-phosphonate at pH 10.6 and 37°C Homo sapiens
0.005
-
 1-deoxysphinganine 1-phosphonate at pH 10.6 and 37°C Symbiobacterium thermophilum
0.0056
-
 (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
0.0063
-
 (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens
0.0091
-
 (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
0.0164
-
 (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens
0.0175
-
 (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
0.019
-
 (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens
0.0204
-
 (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
0.0367
-
 (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0024
-
 at pH 10.6 and 37°C Homo sapiens 2-vinyldihydrosphingosine 1-phosphate
0.0024
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum 2-vinyldihydrosphingosine 1-phosphate
0.0052
-
 at pH 10.6 and 37°C Homo sapiens (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0101
-
 at pH 10.6 and 37°C Homo sapiens (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0108
-
 at pH 10.6 and 37°C Homo sapiens (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0117
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0129
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0138
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.016
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0218
-
 at pH 10.6 and 37°C Homo sapiens (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0229
-
 at pH 10.6 and 37°C Homo sapiens (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0243
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.025
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0257
-
 at pH 10.6 and 37°C Homo sapiens (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0257
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0272
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0283
-
 at pH 10.6 and 37°C Homo sapiens (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0288
-
 at pH 10.6 and 37°C Homo sapiens (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.047
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum phosphopyridoxyl sphinganine 1-phosphate
0.0524
-
 at pH 10.6 and 37°C Homo sapiens FTY720
0.0524
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum FTY720
0.0534
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum phosphopyridoxyl sphingosine 1-phosphate
0.0811
-
 at pH 10.6 and 37°C Homo sapiens phosphopyridoxyl sphinganine 1-phosphate
0.089
-
 at pH 10.6 and 37°C Homo sapiens phosphopyridoxyl sphingosine 1-phosphate