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Literature summary for 4.1.2.27 extracted from

  • Sanllehi, P.; Abad, J.L.; Casas, J.; Delgado, A.
    Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase) (2016), Chem. Phys. Lipids, 197, 69-81 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-4-[(3R)-4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl]phthalazine-6-carbonitrile
-
Homo sapiens
1-deoxydihydrosphingosine 1-phosphonate competitive inhibitor Homo sapiens
2-vinylsphinganine 1-phosphate
-
Homo sapiens
4-amino-N-[4-(1H-imidazol-1-yl)benzyl]-5-oxo-2-(piperidin-1-yl)-8-(tetrahydrofuran-2-ylmethyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
Homo sapiens
4-deoxypyridoxine
-
Homo sapiens
6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
-
Homo sapiens
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
-
Homo sapiens
FTY720
-
Homo sapiens
additional information not inhibited by (S)-FTY720P Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Homo sapiens
-
phosphoethanolamine + palmitaldehyde
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
Homo sapiens phosphoethanolamine + palmitaldehyde
-
ir

Synonyms

Synonyms Comment Organism
sphingosine-1-phosphate lyase
-
Homo sapiens
SPL
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
1-deoxydihydrosphingosine 1-phosphonate pH and temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0024
-
pH and temperature not specified in the publication Homo sapiens 2-vinylsphinganine 1-phosphate
0.0524
-
pH and temperature not specified in the publication Homo sapiens FTY720