Literature summary for 4.1.2.27 extracted from

de la Garza-Rodea, A.S.; Baldwin, D.M.; Oskouian, B.; Place, R.F.; Bandhuvula, P.; Kumar, A.; Saba, J.D.
Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression (2014), FASEB J., 28, 506-519.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8R0X7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
myoblast	sphingosine-1-phosphate lyase is induced during myoblast differentiation	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Sgpl1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	a myoblast sphingosine-1-phosphate lyase-knockdown cell accumulates intracellular and extracellular sphingosine-1-phosphate and fails to form myotubes under conditions that normally stimulate myogenic differentiation. Under differentiation conditions, knockdown cells also demonstrate delayed induction of myogenic microRNAs, miR-1, miR-206, and miR-486. Knockdown cells successfully differentiate when treated with an S1P1 agonist, S1P2 antagonist, and combination treatments, which also increase myogenic miRNA levels. Knockdown cells transfected with mimics for miR-1 or miR-206 also overcome the differentiation block	Mus musculus

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Release 2023.1 (January 2023)