Protein Variants | Comment | Organism |
---|---|---|
H129A | the mutation drastically impairs enzyme activity | Saccharomyces cerevisiae |
H129A | the mutation drastically impairs enzyme activity | Symbiobacterium thermophilum |
Y105F | inactive | Saccharomyces cerevisiae |
Y174F | the mutant is partially active | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-deoxydihydrosphingosine 1-phosphonate | - |
Homo sapiens | |
1-deoxydihydrosphingosine 1-phosphonate | - |
Myxococcus xanthus | |
1-deoxydihydrosphingosine 1-phosphonate | - |
Saccharomyces cerevisiae | |
1-deoxydihydrosphingosine 1-phosphonate | - |
Symbiobacterium thermophilum | |
2-acetyl-4-tetrahydroxybutyl-imidazole | - |
Homo sapiens | |
2-acetyl-4-tetrahydroxybutyl-imidazole | - |
Myxococcus xanthus | |
2-acetyl-4-tetrahydroxybutyl-imidazole | - |
Saccharomyces cerevisiae | |
2-acetyl-4-tetrahydroxybutyl-imidazole | - |
Symbiobacterium thermophilum | |
2-vinyldihydro-sphingosine 1-phosphate | - |
Homo sapiens | |
2-vinyldihydro-sphingosine 1-phosphate | - |
Myxococcus xanthus | |
2-vinyldihydro-sphingosine 1-phosphate | - |
Saccharomyces cerevisiae | |
2-vinyldihydro-sphingosine 1-phosphate | - |
Symbiobacterium thermophilum | |
Ca2+ | - |
Homo sapiens | |
Ca2+ | - |
Myxococcus xanthus | |
Ca2+ | - |
Saccharomyces cerevisiae | |
Ca2+ | - |
Symbiobacterium thermophilum | |
FTY720 | also called fingolimod | Homo sapiens | |
FTY720 | also called fingolimod | Myxococcus xanthus | |
FTY720 | also called fingolimod | Saccharomyces cerevisiae | |
FTY720 | also called fingolimod | Symbiobacterium thermophilum | |
LX2931 | - |
Homo sapiens | |
LX2931 | - |
Myxococcus xanthus | |
LX2931 | - |
Saccharomyces cerevisiae | |
LX2931 | - |
Symbiobacterium thermophilum | |
threo-dihydro-sphingosine 1-phosphate | - |
Homo sapiens | |
threo-dihydro-sphingosine 1-phosphate | - |
Myxococcus xanthus | |
threo-dihydro-sphingosine 1-phosphate | - |
Saccharomyces cerevisiae | |
threo-dihydro-sphingosine 1-phosphate | - |
Symbiobacterium thermophilum | |
Zn2+ | - |
Homo sapiens | |
Zn2+ | - |
Myxococcus xanthus | |
Zn2+ | - |
Saccharomyces cerevisiae | |
Zn2+ | - |
Symbiobacterium thermophilum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Saccharomyces cerevisiae | 16020 | - |
membrane | - |
Myxococcus xanthus | 16020 | - |
membrane | - |
Symbiobacterium thermophilum | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Myxococcus xanthus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Symbiobacterium thermophilum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | the human SGPL1 gene is ubiquitously expressed with the exception of erythrocytes and platelets and its expression is linked to tissues undergoing rapid cell turnover | Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine 1-phosphate | - |
Homo sapiens | phosphoethanolamine + (2E)-hexadecenal | - |
ir | |
sphingosine 1-phosphate | - |
Saccharomyces cerevisiae | phosphoethanolamine + (2E)-hexadecenal | - |
ir | |
sphingosine 1-phosphate | - |
Myxococcus xanthus | phosphoethanolamine + (2E)-hexadecenal | - |
ir | |
sphingosine 1-phosphate | - |
Symbiobacterium thermophilum | phosphoethanolamine + (2E)-hexadecenal | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
Dpl1p | - |
Saccharomyces cerevisiae |
sphingosine-1-phosphate lyase | - |
Homo sapiens |
sphingosine-1-phosphate lyase | - |
Saccharomyces cerevisiae |
sphingosine-1-phosphate lyase | - |
Myxococcus xanthus |
sphingosine-1-phosphate lyase | - |
Symbiobacterium thermophilum |
SPL | - |
Homo sapiens |
SPL | - |
Saccharomyces cerevisiae |
SPL | - |
Myxococcus xanthus |
SPL | - |
Symbiobacterium thermophilum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Homo sapiens | |
pyridoxal 5'-phosphate | dependent on | Saccharomyces cerevisiae | |
pyridoxal 5'-phosphate | dependent on | Myxococcus xanthus | |
pyridoxal 5'-phosphate | dependent on | Symbiobacterium thermophilum |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | SGPL1 gene expression is downregulated in colon cancer and is upregulated in certain malignant tissues, for example, in ovarian cancers as well as in the skin of patients suffering from atopic dermatitis | down |
General Information | Comment | Organism |
---|---|---|
metabolism | SPL functions as the exit gate of the sphingolipid metabolism | Homo sapiens |
metabolism | SPL functions as the exit gate of the sphingolipid metabolism | Saccharomyces cerevisiae |
metabolism | SPL functions as the exit gate of the sphingolipid metabolism | Myxococcus xanthus |
metabolism | SPL functions as the exit gate of the sphingolipid metabolism | Symbiobacterium thermophilum |
physiological function | SPL plays a crucial role in the migration of T-cells from lymphoid tissues by maintaining the sphingosine 1-phosphate gradient necessary for T-cells to egress from the lymph nodes into the blood stream. SPL plays a central role in neutrophil egress from blood to tissues. SPL is a central and crucial regulator of lipid homeostasis. SPL activity is linked to an increase in CER levels in response to stress factors and is involved in apoptosis | Homo sapiens |