Literature summary for 4.1.2.27 extracted from

Berdyshev, E.V.; Gorshkova, I.; Usatyuk, P.; Kalari, S.; Zhao, Y.; Pyne, N.J.; Pyne, S.; Sabbadini, R.A.; Garcia, J.G.; Natarajan, V.
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase (2011), PLoS ONE, 6, e16571.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-deoxypyridoxine	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HPAEC cell	-	Homo sapiens	-
pulmonary artery endothelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sphingosine 1-phosphate	-	Homo sapiens	phosphoethanolamine + (2E)-hexadecenal	-	?

Synonyms

Synonyms	Comment	Organism
S1P lyase	-	Homo sapiens
S1PL	-	Homo sapiens
sphingosine-1-phosphate lyase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	inhibition of S1PL with 4-deoxypyridoxine or knockdown of S1PL with siRNA increases intracellular sphingosine-1-phosphate 3fold, potentiates motility of HPAEC cells to extracellular sphingosine-1-phosphate or serum, and augments activated Rac1 as well as stimulates Rac1 and IQGAP1 translocation to the cell periphery	Homo sapiens

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Release 2023.1 (January 2023)