Literature summary for 4.1.2.27 extracted from

Bandhuvula, P.; Honbo, N.; Wang, G.Y.; Jin, Z.Q.; Fyrst, H.; Zhang, M.; Borowsky, A.D.; Dillard, L.; Karliner, J.S.; Saba, J.D.
S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart (2011), Am. J. Physiol. Heart Circ. Physiol., 300, H1753-H1761.

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Application

Application	Comment	Organism
medicine	S1P lyase is a therapeutic target for ischemia-reperfusion injury of the heart	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
1-{5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl}ethanone	when given overnight at 25 mg/l in drinking water, tetrahydroxybutylimidazole raises sphingosine 1-phosphate levels and reduces SPL activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine 1-phosphate	-	Mus musculus	phosphoethanolamine + omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-(2E)-hexadecenal	-	ir

Synonyms

Synonyms	Comment	Organism
S1P lyase	-	Mus musculus
SPL	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	basal SPL activity is low in wild type cardiac tissue but is activated 3fold in response to 50 min of ischemia	up

General Information

General Information	Comment	Organism
malfunction	hearts of heterozygous SPL knockout mice exhibit reduced SPL activity, elevated sphingosine 1-phosphate levels, smaller infarct size, and increased functional recovery after ischemia-reperfusion injury compared with littermate controls	Mus musculus
physiological function	SPL contributes to oxidative stress by depleting sphingosine 1-phosphate pools available for cardioprotective signaling	Mus musculus

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Release 2023.1 (January 2023)