Literature summary for 4.1.2.27 extracted from

Ling, B.; Chen, L.; Alcorn, J.; Ma, B.; Yang, J.
Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer (2009), Invest. New Drugs, 29, 396-399.

Search for more literature for 4.1.2.27

Application

Application	Comment	Organism
medicine	mRNA expression for both sphingosine kinase and sphingosine 1-phosphate lyase are up-regulated throughout all four stages in human breast cancer patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	breast cancer patient	-

Expression

Organism	Comment	Expression
Homo sapiens	mRNA expression for both sphingosine kinase and sphingosine 1-phosphate lyase are up-regulated throughout all four stages in human breast cancer patients. Exogenous administration of S1P produces a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells but a sigmoid-shaped apoptotic response in breast cancer MCF7 cells. Co-administration of S1P enhances the cytotoxicity of anticancer drug docetaxel against MCF7 cells	up

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Release 2023.1 (January 2023)