Literature summary for 4.1.2.27 extracted from

Min, J.; Van Veldhoven, P.P.; Zhang, L.; Hanigan, M.H.; Alexander, H.; Alexander, S.
Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner (2005), Mol. Cancer Res., 3, 287-296.

Search for more literature for 4.1.2.27

Inhibitors

Inhibitors	Comment	Organism	Structure
carboplatin	cells overexpressing enzyme show increased sensitivity	Homo sapiens
cisplatin	cells overexpressing enzyme show increased sensitivity, mediated by death kinase p38	Homo sapiens
doxorubicin	cells overexpressing enzyme show increased sensitivity	Homo sapiens
additional information	overexpression of enzyme, no change in sensitivity to vincristine, chlorambucil	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in HEK293 or A459 cells	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)