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Literature summary for 4.1.2.27 extracted from

  • Bandhuvula, P.; Tam, Y.Y.; Oskouian, B.; Saba, J.D.
    The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity (2005), J. Biol. Chem., 280, 33697-33700.
    View publication on PubMed

Application

Application Comment Organism
medicine some effects of immune modulator FTY720 are due to disruption of sphingosine-1-phosphate metabolism Mus musculus
medicine some effects of immune modulator FTY720 are due to disruption of sphingosine-1-phosphate metabolism Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
FTY720 in vitro inhibition of enzyme, effects occurring from 300 nM concentrations on, maximal effects at 0.03 mM Homo sapiens
FTY720 in vivo enzyme inhibition concommitantly with lymphopenia, neither enzyme gene expression nor tissue enzyme protein expression is affected by inhibior Mus musculus
FTY720 phosphate less potent inhibitor than FTY720, effects only at 0.03 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
expression in HEK293 cell
-
Mus musculus
-
female, 4 weeks old
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
SPL
-
Mus musculus
SPL
-
Homo sapiens