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Literature summary for 4.1.2.27 extracted from
- Subcellular localisation and membrane topology of sphingosine-1-phosphate lyase in rat liver (1991), J. Biol. Chem., 266, 12502-12507.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chymotrypsin | - |
Rattus norvegicus | |
| Subtilisin | - |
Rattus norvegicus | |
| Thermolysin | - |
Rattus norvegicus | |
| Trypsin | - |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.009 | - |
D-(+)-erythro-dihydrosphingosine 1-phosphate | liver enzyme | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | highest enzyme activity | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | enzyme is responsible for the ultimate step in sphingolipid breakdown, converting phosphorylated long chain bases into ethanolamine phosphate and fatty aldehyde | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-(+)-erythro-dihydrosphingosine 1-phosphate | - |
Rattus norvegicus | ? | - |
? | |
| Dihydrosphingosine 1-phosphonate | - |
Rattus norvegicus | Aminoethylphosphonate + palmidaldehyde | - |
? | |
| additional information | enzyme is responsible for the ultimate step in sphingolipid breakdown, converting phosphorylated long chain bases into ethanolamine phosphate and fatty aldehyde | Rattus norvegicus | ? | - |
? | |
| phytosphingosine 1-phosphate | - |
Rattus norvegicus | ? | - |
? | |
| sphinganine 1-phosphate | D(+)-erythro-dihydrosphingosine-1-phosphate | Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphinganine 1-phosphate | dihydrosphingosine-1-phosphate | Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
? | |
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Release 2023.1 (January 2023)
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