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Literature summary for 4.1.2.25 extracted from

  • Almeida, R.; Loss, O.; Colabardini, A.; Brown, N.; Bignell, E.; Savoldi, M.; Pantano, S.; Goldman, M.; Arst Jr., E.; Goldman, G.
    Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis (2013), G3 (Bethesda), 3, 1129-1141.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
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-
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Synonyms

Synonyms Comment Organism
folA
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Aspergillus nidulans

General Information

General Information Comment Organism
physiological function in isoform folA1 conditional mutant germlings incubated at 30°C for 16 h, the number of nuclei at is comparable with that of wild type germlings. At the restrictive temperature of 44°C, however, 60% of the conidiospores have a single nucleus while wild-type germlings normally undergo two or three nuclear divisions under these conditions. Mutant cells exit from M phase, arrest at 44°C, traverse mitosis and G1 phase, and arrest in S phase in the presence of hydroxyurea. The addition of 1.8 mM folic acid does not improve growth of folA1 mutant strains at 44°C, nor does it improve their growth at 30°C. A mutation in folA can suppress fungal transcription factor crzAD calcium toxicity Aspergillus nidulans